World Anti-Doping Code
PROHIBITED LIST
2010
International Standard
The official text of the Prohibited List adopted by WADA and is published in English and French. In the event of any inconsistency between the English and French versions, the English version will be prevailing.
WORLD ANTI-DOPING CODE
2010 PROHIBITED LIST
Comes into force on January 1, 2010
The use of any drug should be
limited to medical conditions.
All Prohibited Substances are considered as "Specified Substances" except substances listed in classes S1, S2.1 - S2.5, S4.4, S6.a and Prohibited Methods section in the classes M1, M2 and M3.
SUBSTANCES AND METHODS PROHIBITED AT CONSTANT
(COMPETITION OR OUT-OF-COMPETITION PERIOD)
PROHIBITED SUBSTANCES
S1. ANABOLIC AGENTS
The use of anabolic agents is prohibited.
A. Anabolic androgenic steroids (AAS)
a) Exogenous * AAS, including
1-androstenediol (5α-androst-1-ene-3β, 17β-diol)
1-androstenedione (5α-androst-1-ene-3,17-dione)
bolandiol (19 norandrostendiol)
bolasterone
boldenone
boldione (androsta-1 ,4-diene-3 ,17-dione)
gestrinone 4-hydroxytestosterone (4,17 β-dihydroxy-androst-4-ene-3-one)
danazol (17α-ethinyl-17β-hydroxyandrost Eno-4-[2,3-d] isoxazole)
dehydrochlormethyltestosterone (4-chloro-17β-hydroxy-17α-metilandrosta-1 ,4-diene-3-one)
deoxymethyltestosterone (17α-methyl-5α-androsta-2-ene-17β-ol)
drostanolone
gestrinone
4-hydroxytestosterone (4,17 β-digidroksiandrost-4-en-3-one);
calusterone
quinbolone
clostebol
mestanolone
mesterolone
Methandienone (17β-hydroxy-17α-metilandrosta-1 ,4-diene-3-one)
methandriol
metasteron (2α, 17α-dimethyl-5α-androstane-3-one-17β-ol)
metenolone
methyl-1-testosterone (17β-hydroxy-17α-methyl-5α-androst-1-ene-3-one)
methyldienolon (17β-hydroxy-17α-metilestra-4,9-diene-3-one)
methylnortestosterone (17β-hydroxy-17α-metilestra-4-ene-3-one)
methyltestosterone
methyl-trienolone (17β-hydroxy-17α-metilestra-4,9,11-triene-3-one)
mibolerone
19 norandrostendione (estra-4-ene-3,17-dione)
nandrolone
norbolethone
norclostebol
norethandrolone
oxabolone
oxandrolone
oxymesterone
oxymetholone
prostanozol (17β-hydroxy-5α-androstan [3,2-c] pyrazole)
stanozolol
stenbolone
1-testosterone (17β-hydroxy-5α-androst-1-ene-3-one)
tetrahydrogestrinon (18α-homo-pregna-4,9,11-triene-17β-ol-3-one)
trenbolone
fluoxymesterone
formebolone
furazabol (17β-hydroxy-17α-methyl-5α-androsta-[2,3-c]-furazan)
quinbolone
ethylestrenol (19-nor-17α-pregna-4-ene-17-ol)
and other substances with similar chemical structure or similar biological effect.
b) Endogenous ** AAS in the exogenous introduction:
androstenediol (androst-5-ene-3β, 17β-diol)
androstenedione (androst-4-ene-3,17-dione)
dihydrotestosterone (17β-hydroxy-5α-androsta-3-one)
prasterone (digidroepiandrosteron, DHEA)
testosterone,
and the following metabolites and isomers:
4-androstenediol (androst-4-ene-3β, 17β-diol)
5α-androstane-3α, 17α-diol
5α-androstane-3α, 17β-diol
5α-androstane-3β, 17α-diol
5α-androstane-3β, 17β-diol
5-androstenedione (androst-5-ene-3 ,17-dione)
androsta-4-ene-3α, 17α-diol
androsta-4-ene-3α, 17β-diol
androsta-4-ene-3β, 17α-diol
androsta-5-ene-3α, 17α-diol
androsta-5-ene-3α, 17β-diol
androsta-5-ene-3β, 17α-diol
3α-hydroxy-5α-androstan-17-one
3β-hydroxy-5α-androstan-17-one
19-norandrosterone
19-noretioholanolone
epi-testosterone
epi-dihydrotestosterone
2. Other anabolic agents (the list is not exhaustive):
clenbuterol
Selective androgen receptor modulators (SARMs)
tibolone
zeranol
zilpaterol
In this section:
* "Exogenous" refers to a substance that cannot be produced by the body.
** "Endogenous" refers to a substance that can be produced by the body naturally.
S2. PEPTIDE HORMONES, GROWTH FACTORS AND RELATED SUBSTANCES
The following substances and their releasing factors are prohibited:
1. Agents that stimulate the production of erythropoietin (erythropoiesis): Erythropoietin (EPO), darbepoetin (dEPO), gematide, methoxy polyethylene glycol-epoetin beta (CERA);
2. Human chorionic gonadotropin (hCG) and luteinizing hormone (LH) prohibited in males only;
3. Insulin;
4. Corticotropin;
5. Growth Hormone (hGH), insulin growth factors (eg, IGF-1), Mechano Growth Factors (MGFs); platelet-derived growth factor (PDGF), fibroblast growth factors (FGFs), vascular endothelial growth factor (VEGF), hepatocyte growth factor ( HGF), as well as any other growth factor, influencing the synthesis or breakdown of muscle, tendon, and ligament proteins, vascularization, energy consumption, the ability to regenerate or alteration of the type of tissue.
6. Platelet drugs (such as platelet-rich plasma, "centrifugation of blood") injected intramuscularly. Other methods of injection require the declaration of use in accordance with the international standard for TUE and other substances with similar chemical structure or similar biological effect.
S3. BETA-2 AGONISTS
All beta-2 agonists are prohibited, including, where necessary, both optical isomers, except for salbutamol in the maximum daily dose of 1600 micrograms and inhalation use of salmeterol. The latter two cases require a declaration of use in accordance with the International Standard for TUE.
The presence of salbutamol at a concentration exceeding 1000 ng / mL, will not be considered a therapeutic use and will be considered an adverse analytical finding, unless the athlete can demonstrate through a controlled pharmacokinetic study that the result is a consequence of salbutamol inhalation in therapeutic doses (maximum 1600 micrograms a day).
S4. HORMONAL antagonists and modulators
The following classes are prohibited:
1. Aromatase inhibitors including, but not limited to these substances: anastrozole, letrozole, aminoglutethimide, exemestane, formestan, testolactone, androsta-1,4,6-triene-3 ,17-dione (androstatrienedion), 4-androstene-3, 6, 17 trione (6-oxo)
2. Selective estrogen receptor modulators (SERMs), including, but not limited to these substances: raloxifene, tamoxifen, toremifene.
3. Other antiestrogenic substance, including, but not limited to these substances: clomiphene, cyclofenil, fulvestrant.
4. Agents modifying myostatin functions, including, but not limited to myostatin inhibitors.
S5. DIURETICS AND OTHER MASKING AGENTS
Masking agents are prohibited. They include:
Diuretics, probenecid, plasma expanders (for example, glycerol, intravenously injected albumin, dextran, hydroxyethyl starch and mannitol) and other substances with similar biological effects.
Diuretics include:
amiloride
acetazolamide
bumetanide
indapamide
canrenone
metolazone
spironolactone
thiazides (eg, bendroflumetiazid, chlorothiazide, hydrochlorothiazide),
triamterene
furosemide
chlorthalidone
etacrynic acid,
and other substances with similar chemical structure or similar biological effect except drosperinone, pamabrom and locally applied dorzolamina and brinzolamide, which are not prohibited.
Therapeutic Use Exemption is not valid if the urine of an athlete in addition to diuretics contains a prohibited substance with a threshold or subthreshold concentration.
PROHIBITED METHODS
M1. ENHANCEMENT OF OXYGEN TRANSFER
The following are prohibited:
1. Blood doping, including the use of autologous, homologous or heterologous blood or red blood cell products of any origin.
2. Artificially enhancing the uptake, transport or delivery of oxygen, including but not limited to perfluorochemicals, efaproxiral (RSR13) and modified haemoglobin products (e.g. haemoglobin-based blood substitutes, microencapsulated haemoglobin products), excluding supplemental oxygen.
М2. CHEMICAL AND PHYSICAL MANIPULATION
1.Tampering, or attempting to tamper, in order to alter the integrity and validity of Samples collected during Doping Controls is prohibited. These include but are not limited to catheterization, urine substitution and/or adulteration (e.g. proteases).
2. Intravenous infusions are prohibited except for those legitimately received in the course of hospital admissions or clinical investigations.
МЗ. GENE DOPING
The following, with the potential to enhance athletic performance, are prohibited:
1. The transfer of cells or genetic elements (e. g. DNA, RNA);
2. The use of pharmacological or biological agents that alter gene expression.
Peroxisome Proliferator Activated Receptor d (PPARd) agonists (e.g. GW 1516) and PPARd-AMP-activated protein kinase (AMPK) axis agonists (e.g. AICAR) are prohibited.
SUBSTANCES AND METHODS,
PROHIBITED IN-COMPETITION
In addition to the categories S1 to S5 and M1 to M3 defined above, the following categories are prohibited in competition:
PROHIBITED SUBSTANCES
S6. STIMULANTS
All stimulants (including both optical isomers where relevant) are prohibited, except imidazole derivatives for topical use and those stimulants included in the 2010 Monitoring Program*.
Stimulants include:
а) Non-Specified Stimulants:
adrafinil
amiphenazole
amfepramone
amphetamine
amphetaminil
benzphetamine
benzylpiperazine
benfluorex
bromantan
clobenzorex
cocaine
cropropamide
crotetamide
dimethylamphetamine
etilamphetamine
famprofazone
fencamine
fenetylline
fenfluramine
fenproporex
furfenorex
mefenorex
mephentermine
mesocarb
methamphetamine(d-)
p-methylamphetamine
methylenedioxyamphetamine
methylenedioxymethamphetamine
methylhexaneamine (dimethylpentylamine)
modafinil
norfenfluramine
phendimetrazine
phenmetrazine
phentermine
4-phenylparacetam (carphedon)
phenylamine
prolintane
A stimulant not expressly listed in this section is a Specified Substance.
б) Specified Stimulants (examples):
adrenaline**
cathine***
ephedrine****
etamivan
etilefrine
fenbutrazate
fencamfamin
heptaminol
isometheptene
levmethamphetamine
meclofenoxate
methylephedrine****
methylpenidate
nikethamide
norfenefrine
octopamine
exilofrine
parahydroxyamphetamine
pemoline
pentetrazol
phenpromethamine
propylhexedrine
pseudoephedrine*****
selegiline
sibutramine
strychnine
tuaminoheptane
and other substances with a similar chemical structure or similar biological effect(s).
*The following substances included in the 2010 Monitoring Program (buproplon, caffeine, phenylephrine, phenylpropanolamine, pipradol, synephrine) are not considered as Prohibited Substances.
** Adrenaline associated with local anaesthetic agents or by local administration (e.g. nasal, ophtalmologic) is not prohibited.
*** Cathine is prohibited when its concentration in urine is greater than 5 micrograms per milliliter.
**** Each of ephedrine and methylephedrine is prohibited when its concentration in urine is greater than 10 micrograms per milliliter.
***** Pseudoephedrine is prohibited when its concentration in urine is greater than 150 micrograms per milliliter.
S7. NARCOTICS
The following narcotics are prohibited:
buprenorphine
dextromoramide
diamorphine (heroin)
fentanyl and its derivatives
hydromorphone
methadone
morphine
oxycodone
oxymorphone
pentazocine
pethidine.
S8. CANNABINOIDS
Natural or synthetic D9-tetrahydrocannabinol (THC) and THC-like cannabinoids (e.g. hashish, marijuana, HU-210) are prohibited
S9. GLUCOCORTICOSTEROIDS
All glucocorticosteroids are prohibited when administered by oral, intravenous, intramuscular or rectal routes.
In accordance with the International Standard for Therapeutic Use Exemptions, a declaration of Use must be completed by the Athlete for glucocorticosteroids administered by intraarticular, periarticular, peritendinous, epidural, intradermal and inhalation routes, except as noted below.
Topical preparations when used for auricular, buccal, dermatological (including iotophoresis/phonophoresis), gingival, nasal, ophthalmic and perianal disorders are not prohibited and require neither a Therapeutic Use Exemption nor a declaration of Use.
SUBSTANCES PROHIBITED IN PARTICULAR SPORTS
Р1. ALCOHOL
Alcohol (ethanol) is prohibited In-Competition only, in the following sports. Detection will be conducted by analyses of breath and/or blood. The doping violation threshold (haematological values) is 0.10g/L.
Aeronautic (FAI)
Archery (FITA)
Automobile (FIA)
Karate (WKF)
Modern Pentathlon (UIPM) for disciplines involving shooting
Motorcycling (FIM)
Ninepin and Tenpin Bowling (FIQ)
Powerboating (UIM)
Р2. BETA-BLOCKERS
Unless otherwise specified, beta-blockers are prohibited In-Competition only, in the following sports:
Aeronautic (FAI)
Archery (FITA) (also prohibited Out-of-Competition)
Automobile (FIA)
Billiards and Snooker (WCBS)
Bobsleigh (FIBT)
Boules (CMSВ)
Bridge (FMB)
Curling (WCF)
Golf (IGF)
Gymnastics (FIG)
Motorcycling (FIM)
Modern Pentathlon (UIPM) for disciplines involving shooting
Ninepin and Tenpin Bowling (FIQ)
Powerboating (UIM)
Sailing (ISAF) for match race helms only
Shooting (ISSF, IPC) also prohibited Out-of-Competition
Skiing/Snowboarding (FIS) in ski jumping, freestyle aerials/halfpipe and snowboard halfpipe/big air
Wrestling (FILA)
Beta-blockers include, but are not limited to, the following:
acebutolol
alprenolol
atenolol
betaxolol
bisoprolol
bunolol
carteolol
carvedilol
celiprolol
esmolol
labetalol
levobunolol
metipranolol
metoprolol
nadolol
oxprenolol
pindolol
propranolol
sotalol
timolol